IN-VITRO SWELLING STUDIES AND PRELIMINARY BIOCOMPATIBILITY EVALUATIONOF ACRYLAMIDE-BASED HYDROGELS

In this in vitro study, the biocompatibility of acrylamide-based hydro gels such as acrylamide/crotonic and acrylamide/itaconic acid, prepare d by using gamma-rays, has been investigated against some biochemical parameters of human serum. The swelling kinetics of acrylamide/crotoni c and acrylamide/itaconic acid hydrogels are investigated in distilled water and physiological saline solution-and some swelling and diffusi on parameters have been calculated. For the analysis of biocompatibili ty, acrylamide/crotonic and acrylamide/itaconic acid hydrogels are inc ubated in 10 different human sera for 24 h and their biocompatibilitie s with some biochemical parameters have been investigated. No signific ant difference in values before and after the test procedures have bee n found. It is therefore concluded that acrylamide/crotonic and acryla mide/itaconic acid hydrogels are biocompatible.