PREDICTION OF COMPLICATIONS IN GAMMA-KNIFE RADIOSURGERY OF ARTERIOVENOUS-MALFORMATIONS

The incidence of complications following radiosurgical treatment of ar teriovenous malformations (AVM)is presented. A simple relationship exi sts between average dose and risk of complications, and on this basis a model is presented that gives a qualitatively correct description of this relationship. The parameters of the model have been determined u sing a clinical material of 862 AVM treatments to give a quantitativel y correct description of the risk of complications. The dose-response curve is described by a double-exponential function. An accurate descr iption of the dose-response curve at high dose levels is shown to be v ery important in radiosurgery.