LOCALIZATION OF THE MOUSE LISSENCEPHALY-1 GENE TO MOUSE CHROMOSOME 11B3, IN CLOSE PROXIMITY TO D11MIT65

Lissencephaly is a human brain malformation manifested by a smooth cer ebral surface and severe mental retardation. Some of the patients have been shown to have deletions in chromosome 17p13.3, and recently, LIS -1 has been proposed to be the disease-associated gene. We have now ma pped the mouse homolog of LIS-1 to mouse chromosome 11B3 by using fluo rescence in situ hybridization to metaphase chromosomes. The analysis of yeast artificial chromosome clones placed Lis-1 in close proximity to the microsatellite marker D11Mit65.