J. Wojcicki et al., PHARMACOKINETICS OF PHENAZONE (ANTIPYRINE) IN RABBITS WITH EXPERIMENTAL COMMON BILE-DUCT OBSTRUCTION, British Journal of Pharmacology, 117(1), 1996, pp. 1-4
1 An altered functional state of liver due to experimental cholestasis
could result in a change in the biotransformation of drugs. The aim o
f this study was to evaluate an influence of obstructive cholestasis o
n the pharmacokinetics of phenazone (antipyrine). 2 The investigation
was carried out on male rabbits, randomly allocated into two groups: s
ham-operated and animals with biliary ducts ligation. Phenazone was ad
ministered intragastrically as a probe of drug metabolism. 3 Measureme
nts, i.e. laboratory and pharmacodynamic tests, as well as pharmacokin
etic assays, were performed before the operation as well as 10-12 days
after the bile duct ligation. At the end of the study livers were exa
mined macro- and microscopically and biochemical analysis of the liver
microsomes was performed. 4 The measured pharmacokinetic parameters s
uggested an impaired biotransformation of phenazone in animals with ob
structive cholestasis, leading to a slower drug elimination.