LYMPHOCYTE-ACTIVATION EFFECT OF(1-]-6)-2,5-ANHYDRO-D-GLUCITOL AND IT DERIVATIVES WITH 3,4-DI-O-METHYL AND SULFATE GROUPS

Authors
KAKUCHI T UMEDA S SATOH T YOKOTA K YUHTA T KIKUCHI A MURABAYASHI S
Citation
T. Kakuchi et al., LYMPHOCYTE-ACTIVATION EFFECT OF(1-]-6)-2,5-ANHYDRO-D-GLUCITOL AND IT DERIVATIVES WITH 3,4-DI-O-METHYL AND SULFATE GROUPS, International journal of biological macromolecules, 18(1-2), 1996, pp. 147-148
Citations number
11
Categorie Soggetti
Biology
Journal title
International journal of biological macromolecules → ACNP
ISSN journal
01418130
Volume
18
Issue
1-2
Year of publication
1996
Pages
147 - 148
Database
ISI
SICI code
0141-8130(1996)18:1-2<147:LEOAID>2.0.ZU;2-K
Abstract
(1-->6)-2, 5-Anhydro-3,4-di-O-methyl-D-glucitol (2a) and (1-->6)-2,5-a nhydro-D-glucitol (2c) and its sulfated derivative (2d) were synthesiz ed and their biological activities were evaluated in regards to the ef fects on murine lymphocytes. The polymers showed different effects on the lymphocytes depending on the substituent groups. The sulfated poly mer (2d) induced mitogenic activities, and specifically activated the CD4(-)CD8(-) subset of lymphocytes.