Er. Lewis et Kr. Henry, NONLINEAR EFFECTS OF NOISE ON PHASE-LOCKED COCHLEAR-NERVE RESPONSES TO SINUSOIDAL STIMULI, Hearing research, 92(1-2), 1995, pp. 1-16
It is well known that, in a cochlear afferent axon with background spi
ke activity, a sinusoidal stimulus (tone) of sufficiently low frequenc
y will produce periodic modulation of the instantaneous spike rate, th
e alternating half cycles of which comprise excursions above and below
the mean background spike rate, It also is known that if the amplitud
e of the stimulus is sufficiently small, the instantaneous spike rate
follows very nearly a sinusoidal trajectory through these positive and
negative excursions. For such cases, we define the AC responsiveness
of a primary auditory afferent axon to be the amplitude of sinusoidal
modulation of the instantaneous spike rate divided by the amplitude of
the tone producing that modulation. In the experiments described in t
his paper, changes in AC responsiveness were followed during and after
sudden changes in the background noise level. When the amplitude of t
he tone was sufficiently small relative to that of the noise, we found
that the AC responsiveness can be strongly dependent on the time elap
sed since the last change in noise level, while being nearly independe
nt of the amplitude of the tone itself. Under those circumstances, aft
er transitions between noise levels 20 dB apart, we observed changes i
n AC responsiveness that consistently followed time courses similar to
those of the short-term mean (background) spike rate (approximating t
he adapting response to the noise alone), unfolding over several milli
seconds or tens of milliseconds. At the time of the transition between
noise levels, there was another change in AC responsiveness, which ap
peared to be instantaneous; as the noise level increased, the AC respo
nsiveness immediately increased with it. This seemingly paradoxical ef
fect and the similarity of the time courses of AC responsiveness and s
hort-term mean spike rate both are consistent with a simple, descripti
ve model of spike generation involving the shifting of threshold along
a bell curve.