CARDIOVASCULAR EFFECTS OF LEU-ENKEPHALIN IN THE NUCLEUS-TRACTUS-SOLITARIUS OF THE RAT

Authors
FELDMAN PD PARVEEN N SEZEN S
Citation
Pd. Feldman et al., CARDIOVASCULAR EFFECTS OF LEU-ENKEPHALIN IN THE NUCLEUS-TRACTUS-SOLITARIUS OF THE RAT, Brain research, 709(2), 1996, pp. 331-336
Citations number
15
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
709
Issue
2
Year of publication
1996
Pages
331 - 336
Database
ISI
SICI code
0006-8993(1996)709:2<331:CEOLIT>2.0.ZU;2-J
Abstract
Microinjections of Leu-enkephalin into the dorsal vagal complex induce d hypotension and bradycardia. Both naloxone, given at a dose conferri ng selectivity for mu receptors, and the delta antagonist ICI 154,129 prevented the cardiovascular effects of Leu-enkephalin. Naloxone was a lso found to decrease the gain of the baroreflex. These results sugges t that Leu-enkephalin is involved in cardiovascular regulation through activation of delta-, and possibly mu-, opioid receptors in the dorsa l vagal complex.