A COMPARISON OF MICONAZOLE, KETOCONAZOLE AND FLUCONAZOLE IN THEIR EFFECTS ON TEMPERATURE-DEPENDENT GROWTH AND THERMAL DEATH IN CANDIDA-ALBICANS

A strain of Candida albicans isolated from human sputum exhibited an a ssociative temperature profile, with the initial maximum temperature = 42 degrees C, the final maximum temperature = 38 degrees C, and the m inimum temperature of thermal death = 33 degrees C, showed a decrease in its cardinal temperatures and a reduction in the specific rates of growth and thermal death throughout the novel temperature ranges in th e presence of either 25 mu M of miconazole, ketoconazole or fluconazol e. In the concentration range 0-30 mu M, each drug concertedly depress ed the kinetic and energetic parameters of growth, with lesser variati on on the specific glucose transfer rate. The overall effect of micona zole was the greatest (up to one order of magnitude), while that of fl uconazole was the least.