DIABETIC MICROANGIOPATHIC HEMOLYTIC-ANEMIA AND THROMBOCYTOPENIA WITH ANTIPHOSPHOLIPID SYNDROME

A 38-year-old man with a la-year history of noninsulin-dependent diabe tes mellitus with rapidly progressive diabetic complications presented with microangiopathic hemolytic anemia and thrombocytopenia. He had n o disorders that could induce microangiopathic hemolytic anemia other than diabetic microangiopathy, In addition, there was a significant ne gative correlation between serum lactate dehydrogenase levels and peri pheral platelet counts, which suggested that the hemolysis and thrombo cytopenia occurred through the same mechanism, Activated partial throm boplastin time was slightly prolonged, and lupus anticoagulant and ant iphospholipid immunoglobulin G antibodies were positive. Both the hemo lysis and the thrombocytopenia spontaneously improved after the initia tion of hemodialysis, This is a unique case of diabetic microangiopath ic hemolytic anemia and thrombocytopenia in which antiphospholipid syn drome also may be involved.