FROM PHOSPHONATES TO CATALYTIC ANTIBODIES - A NOVEL ROUTE TO PHOSPHONOESTER TRANSITION-STATE ANALOGS AND HAPTENS

Authors
TAWFIK DS ESHHAR Z GREEN BS
Citation
Ds. Tawfik et al., FROM PHOSPHONATES TO CATALYTIC ANTIBODIES - A NOVEL ROUTE TO PHOSPHONOESTER TRANSITION-STATE ANALOGS AND HAPTENS, Phosphorus, sulfur and silicon and the related elements, 76(1-4), 1993, pp. 383-386
Citations number
4
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Phosphorus, sulfur and silicon and the related elements → ACNP
ISSN journal
10426507
Volume
76
Issue
1-4
Year of publication
1993
Pages
383 - 386
Database
ISI
SICI code
1042-6507(1993)76:1-4<383:FPTCA->2.0.ZU;2-T
Abstract
We present here a newly developed approach based on DBU catalyzed tran sesterification of bis-PNP-phosphonates, used for the preparation of p hosphonoesters and their protein conjugates. These are being used, as transition state analogs, to elicit catalytic antibodies having enzyme -like properties.