SYNTHESIS AND HIV-1 REVERSE-TRANSCRIPTASE INHIBITION-ACTIVITY OF FUNCTIONALIZED PYROPHOSPHATE ANALOGS

Authors
MCKENNA CE KHARE A JU JY LI ZM DUNCAN G CHENG YC KILKUSKIE R
Citation
Ce. Mckenna et al., SYNTHESIS AND HIV-1 REVERSE-TRANSCRIPTASE INHIBITION-ACTIVITY OF FUNCTIONALIZED PYROPHOSPHATE ANALOGS, Phosphorus, sulfur and silicon and the related elements, 76(1-4), 1993, pp. 399-402
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Phosphorus, sulfur and silicon and the related elements → ACNP
ISSN journal
10426507
Volume
76
Issue
1-4
Year of publication
1993
Pages
399 - 402
Database
ISI
SICI code
1042-6507(1993)76:1-4<399:SAHRIO>2.0.ZU;2-A
Abstract
A new approach, ketone derivatization, for introducing desired functio nality into the alpha-keto pyrophosphate analogues oxophosphonoacetic acid (COPAA) and oxomethanediphosphonic acid (COMDP) is exemplified in the synthesis of several COPAA and COMDP hydrazones with specific fun ctional groups. The preparation of tetraalkyl COMDP esters is also des cribed. Inhibition of HIV-1 reverse transcriptase (isolated enzyme) an d of p24 production by HIV-1 (virus-infected H9 cells) by hydrazone de rivatives of COPAA and COMDP is briefly discussed.