BISPHOSPHONATES - MOLECULAR MODELING, STRUCTURE-ACTIVITY-RELATIONSHIPS AND THE RATIONAL DESIGN OF NEW ANALOGS

Authors
EBETINO FH KAAS SM CRAWFORD RJ
Citation
Fh. Ebetino et al., BISPHOSPHONATES - MOLECULAR MODELING, STRUCTURE-ACTIVITY-RELATIONSHIPS AND THE RATIONAL DESIGN OF NEW ANALOGS, Phosphorus, sulfur and silicon and the related elements, 76(1-4), 1993, pp. 411-414
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Phosphorus, sulfur and silicon and the related elements → ACNP
ISSN journal
10426507
Volume
76
Issue
1-4
Year of publication
1993
Pages
411 - 414
Database
ISI
SICI code
1042-6507(1993)76:1-4<411:B-MMS>2.0.ZU;2-T
Abstract
A combination of 2D NMR spectroscopy, x-ray crystallography and molecu lar mechanics have been used in the structure determination of a confo rmationally rigid antiresorptive active bisphosphonate. This rigid str ucture has provided a template from which other conformationally restr icted actives have been successfully designed.