DESIGN AND SYNTHESIS OF NEW HYPOCHOLESTEROLEMIC ORGANOSILANES WITH ANTIOXIDANT PROPERTIES

Authors
GOTTELAND JP DELHON A JUNQUERO D OMS P HALAZY S
Citation
Jp. Gotteland et al., DESIGN AND SYNTHESIS OF NEW HYPOCHOLESTEROLEMIC ORGANOSILANES WITH ANTIOXIDANT PROPERTIES, Bioorganic & medicinal chemistry letters, 6(5), 1996, pp. 533-538
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
5
Year of publication
1996
Pages
533 - 538
Database
ISI
SICI code
0960-894X(1996)6:5<533:DASONH>2.0.ZU;2-J
Abstract
(Arylamino)methylsilane derivatives 3 have been prepared and identifie d as potent inhibitors of human LDL oxidation mediated by copper(II). Combination of this property with the structural requirement of squale ne epoxidase inhibitors led to the design and synthesis of the (arylam ino)methylsilane derivative 4 which was characterised as the first pot ent, orally active squalene epoxidase inhibitor with antioxidant prope rties.