MECHANISM-BASED INACTIVATION OF ALPHA-CHYMOTRYPSIN

Authors
OHBA T TSUCHIYA N NISHIMURA K IKEDA E WAKAYAMA J TAKEI H
Citation
T. Ohba et al., MECHANISM-BASED INACTIVATION OF ALPHA-CHYMOTRYPSIN, Bioorganic & medicinal chemistry letters, 6(5), 1996, pp. 543-546
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
5
Year of publication
1996
Pages
543 - 546
Database
ISI
SICI code
0960-894X(1996)6:5<543:MIOA>2.0.ZU;2-T
Abstract
The peptidyl ester derivatives of 2,2-dichlorocyclopropanol and the am ide derivative of 2,2-dichlorocyclopropylamine were prepred as novel m echanism-based inactivators of alpha-chymotrypsin. The esters inactiva ted alpha-chymotrypsin irreversibly but the amide did not show any irr eversible inhibitory activity toward alpha-chymotrypsin.