THE ANTIINFLUENZA ACTIVITY OF PYRROLO[2,3-D]PYRIMIDINES

Authors
SZNAIDMAN ML MEADE EA BEAUCHAMP LM RUSSELL S TISDALE M
Citation
Ml. Sznaidman et al., THE ANTIINFLUENZA ACTIVITY OF PYRROLO[2,3-D]PYRIMIDINES, Bioorganic & medicinal chemistry letters, 6(5), 1996, pp. 565-568
Citations number
5
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
5
Year of publication
1996
Pages
565 - 568
Database
ISI
SICI code
0960-894X(1996)6:5<565:TAAOP>2.0.ZU;2-5
Abstract
From a group of pyrrolo[2,3-d]pyrimidine compounds that have been scre ened against influenza virus, one derivative, 4-(3-piperidinyl benzyla mino)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine (9), has shown promising ac tivity against both the A and B strains. The compound had activity com parable to amantadine, but was inactive when given orally. 4-(Substitu tedphenyl ethylamino)-2-methyl-7H-pyrrolo[2,3-d]pyrimidines showed no improved activity.