S-NITROSATION OF PROTEINS BY N-METHYL-N-NITROSOANILINES

Authors
GUO ZM MCGILL A YU LB LI J RAMIREZ J WANG PG
Citation
Zm. Guo et al., S-NITROSATION OF PROTEINS BY N-METHYL-N-NITROSOANILINES, Bioorganic & medicinal chemistry letters, 6(5), 1996, pp. 573-578
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
5
Year of publication
1996
Pages
573 - 578
Database
ISI
SICI code
0960-894X(1996)6:5<573:SOPBN>2.0.ZU;2-A
Abstract
Substituted N-methyl-N-nitrosoanilines are found to function as stable , potent, nitrosating agents for S-nitrosation and inactivation of cys teine proteases such as papain, bromelain and aldehyde dehydrogenase u nder physiological conditions in a time and concentration dependent ma nner. Spectroscopic studies on the reaction product have proved that t he mechanism of the inactivation is a S-nitrosation of the protein.