Allergy to natural latex proteins has been recently recognized as a da
ngerous entity among health care professionals. Cutaneous symptoms rel
ated to latex glove use vary from the redness and scaling of contact d
ermatitis to urticaria, In addition, anaphylactic reactions have been
reported. We report the spectrum of reactions to latex glove use in 93
members of our emergency department (ED) staff during a one-month stu
dy period, In addition, we attempt to correlate these symptoms with se
rologic evidence of atopy and latex allergy, Eighty-four of these subj
ects underwent total serum immunoglobulin E and latex-specific radioal
lergosorbent test (RAST) testing, Fifty-four percent of subjects repor
ted symptoms relating to latex glove use, categorized as either contac
t dermatitis (48.4%) or urticaria (5.4%), Of the urticaria group, two
subjects reported additional symptoms related to latex glove use such
as rhinitis, conjunctivitis, or sneezing, All three groups of subjects
(asymptomatic, contact dermatitis, and urticaria) were alike with res
pect to age, sex, and race, The urticaria group reported a higher inci
dence of environmental allergies (chi(2), P = 0.02). Serum total immun
oglobulin E levels and latex-specific RAST results did not differ amon
g the three groups, The one subject with a positive latex-specific RAS
T reported urticarial and nasoocular symptoms when exposed to latex gl
oves, Seventeen percent of symptomatic subjects reported decreased use
of latex gloves because of these symptoms, It was concluded that many
members of our pediatric ED staff exhibit a sensitivity to latex anti
gens, Clinical symptoms, rather than serologic testing, must be used t
o identify latex-sensitive individuals in this setting, Recommendation
s are offered to assist In the identification and management of hospit
al personnel who exhibit allergy to latex-containing products.