Claudication is exercise-induced lower extremity pain that is caused b
y ischemia and relieved by rest. This underreported condition affects
at least 10 percent of persons over 70 years of age and 2 percent of t
hose 37 to 69 years of age. Claudication is usually caused by atherosc
lerotic narrowing of the arteries that supply blood to the lower extre
mities. The diagnosis may be suspected based on the history and the ph
ysical examination, and it is confirmed by Doppler segmental pressures
and an ankle/brachial index. Initial treatment includes vigorous risk
factor modification and an exercise program. Further treatment includ
es pentoxifylline and, occasionally, endovascular or bypass procedures
.