APPLICATION OF THE CYTOKINESIS-BLOCKED MICRONUCLEUS ASSAY TO PATIENTSTREATED BY CHEMOTHERAPY OR CONCOMITANT RADIOTHERAPY AND CHEMOTHERAPY

Authors
DUFFAUD F FAVRE R LEHUCHERMICHEL MP BOTTA A
Citation
F. Duffaud et al., APPLICATION OF THE CYTOKINESIS-BLOCKED MICRONUCLEUS ASSAY TO PATIENTSTREATED BY CHEMOTHERAPY OR CONCOMITANT RADIOTHERAPY AND CHEMOTHERAPY, Medical science research, 24(2), 1996, pp. 95-97
Citations number
17
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Medical science research → ACNP
ISSN journal
02698951
Volume
24
Issue
2
Year of publication
1996
Pages
95 - 97
Database
ISI
SICI code
0269-8951(1996)24:2<95:AOTCMA>2.0.ZU;2-S
Abstract
We applied cytokinesis-block micronucleus assay to measure the chromos ome damage in lymphocytes of 32 cancer patients undergoing chemotherap y (17 patients) or concomitant radio and chemotherapy (15 patients). M easurements before treatment (T0) and just before the second chemother apy cycle (T1) showed a significant increase in the micronucleated cel l rates for the radio- and chemotherapy group but no significant incre ase between T0 and T1 for the chemotherapy group. Different hypotheses to explain these results are discussed. The most significant explanat ion is based on the mechanism of action of concomitant radio- and chem otherapy.