W. Fabry et al., COMPARISON OF THE E-TEST AND A PROPORTION DILUTION METHOD FOR SUSCEPTIBILITY TESTING OF MYCOBACTERIUM-AVIUM COMPLEX, Journal of Medical Microbiology, 44(3), 1996, pp. 227-230
The newly developed E test was compared with an extended 1% proportion
dilution method for determining the susceptibility of Mycobacterium a
vium complex (MAC) strains to amikacin, streptomycin, fusidic acid, ri
fampicin, clarithromycin, ciprofloxacin, ofloxacin and fleroxacin. For
all antibiotics tested except clarithromycin and ciprofloxacin, no mo
re than one strain gave a different susceptibility result with the two
methods. The discrepant results occurred near the chosen breakpoint c
oncentration of clarithromycin and outside the concentration range of
the E test for ciprofloxacin. For the minimum inhibitory concentration
(MIG) values obtained within the range of antibiotic concentrations t
ested, there was good correlation between the two methods; the MICs di
ffered by more than one two-fold dilution in no more than two strains
per antibiotic. It is concluded that the E test is suitable for suscep
tibility testing of MAC.