SYNTHESIS OF SOME NEW BIOLOGICALLY-ACTIVE 2-PHENYL-6-IODO-3-SUBSTITUTED-4(3H) QUINAZOLINONES

2-Phenyl-6-iodo-3, 1-benzoxazine-4-one (1) was reacted with p-aminodip henylamine to give (2), which was used for the synthesis of acridine a nd phenothiazine derivatives (4), (5), (6) and (7), respectively. Acet ylation of (2), by acetyl chloride afforded N-acetyl derivative (3), I nteraction of (1), with p-phenylenediamine in dry pyridine gave (8), i ts chloroacetyl derivative was prepared and reacted with malononitrile , ethyl cyanoacetate or diethyimalonate to furnish the pyrrolidinones (10a-c), respectively. Also, compound (8) was used as starting materia l in the synthesis of many heterocyclic compounds (12-17), respectivel y. The structure of the products have been established on the basis of elemental analysis and spectral data. Compounds (6a) and (7) showed v ery promising activity against bacteria as compared to standard antibi otic Gentamycin.