REACTION OF BENZONITRILE OXIDE WITH 3-ETHOXY-4-HYDROXYBENZAL ANILINESAND ANTIFUNGAL ACTIVITY OF THE PRODUCTS

Authors
MANRAO MR GILL KK SHARMA JR KALSI PS
Citation
Mr. Manrao et al., REACTION OF BENZONITRILE OXIDE WITH 3-ETHOXY-4-HYDROXYBENZAL ANILINESAND ANTIFUNGAL ACTIVITY OF THE PRODUCTS, Indian Journal of Heterocyclic Chemistry, 5(2), 1995, pp. 151-152
Citations number
2
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian Journal of Heterocyclic Chemistry → ACNP
ISSN journal
09711627
Volume
5
Issue
2
Year of publication
1995
Pages
151 - 152
Database
ISI
SICI code
0971-1627(1995)5:2<151:ROBOW3>2.0.ZU;2-#
Abstract
Condensation of benzonitrile oxide, generated in situ, by the reaction of triethylamine on hydroxamoyl chloride, with 3-ethoxy-4-hydroxy-ben zalanilines has resulted in the formation of cycloadducts which have b een identified and confirmed as 1,2,4-oxadiazoline derivatives on the basis of elemental analysis and spectral studies. The products were te sted in vitro for their antifungal activity and it has been observed t hat the presence of ethoxy group in the phenyl ring increases the anti fungal activity of the compounds.