Formaldehyde is a well known toxic air impurity affecting the upper re
spiratory tract. It rapidly forms methylene glycol in water. Reactions
of the hydrated formaldehyde with nasal mucus were studied by C-13 NM
R spectroscopy. In NMR spectra methylene glycol dominated and only min
or signals from possible reactions were observed. This finding suggest
s that nasal mucus effectively protects nasal epithelium against forma
ldehyde.