B. Quinio et al., SELECTIVE DECONTAMINATION OF THE DIGESTIVE-TRACT IN MULTIPLE TRAUMA PATIENTS - A PROSPECTIVE DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED STUDY, Chest, 109(3), 1996, pp. 765-772
Study objective: The aims of the study were to evaluate the technique
of selective digestion decontamination (SDD) in preventing the develop
ment of nosocomial infections in a selected population and to assess t
he effects on colonization of the oropharynx, nares, and bronchi. A fi
nancial assessment was also performed. Design: Prospective, double-bli
nd, randomized, placebo-controlled trial using amphotericin B, colisti
n sulfate (polymixin E), and gentamicin applied to the nares, the orop
harynx, and enterally; no parenteral antibiotics were given during the
study period. The SDD was applied every 6 h during the study period.
Setting: Multidisciplinary ICU in a university hospital. Patients: A t
otal of 148 trauma patients admitted emergently and intubated within l
ess than 24 h were enrolled. Seventy-two patients who received placebo
and 76 treated patients were analyzed on an ''intention-to-treat'' ba
sis. Interventions: Microbiologic surveillance samples of oropharyngea
l and bronchial secretions, urine, and any other potentially infected
sites were taken at the time of ICU admission and twice weekly thereaf
ter until discharge from the unit. Measurements and results: With the
use of SDD, colonization was significantly reduced in the oropharynx a
nd nares (p<0.05) but not in bronchi. However, episodes of bronchopneu
monia were significantly reduced (19 in the active group vs 37 in the
placebo group; p<0.01). Staphylococcus aureus remained the main potent
ial pathogen causing bronchial colonization and subsequent bronchopneu
monia, There was no reduction in the incidence of other infections. Da
ys in the ICU, duration of mechanical ventilation, and mortality rate
were unchanged. After the use of SDD, Gram-positive colonization tende
d to increase and this was mainly due to methicillin-resistant coagula
se-negative staphylococci. The total cost of antibiotic therapy ($62,1
17 [US] in the placebo group and $36,008 in the SDD group) was decreas
ed by 42% with the use of SDD. Clinically important complications of S
DD were not encountered. Conclusions: The use of SDD in this populatio
n of trauma patients reduced the incidence of bronchopneumonia and the
total charge for antibiotics. Stay in the ICU, mechanical ventilation
duration, and mortality rate were unchanged. Methicillin-resistant co
agulase-negative staphylococci were selected by SDD in some patients a
nd the clinical relevance of this colonization needs further evaluatio
n.