7,12-DIMETHYLBENZ[A]ANTHRACENE-INDUCED EARLY SQUAMOUS-CELL CARCINOMA IN THE GOLDEN SYRIAN-HAMSTER - EVALUATION OF AN ANIMAL-MODEL AND COMPARISON WITH EARLY FORMS OF HUMAN SQUAMOUS-CELL CARCINOMA IN THE UPPER AERODIGESTIVE TRACT
S. Andrejevic et al., 7,12-DIMETHYLBENZ[A]ANTHRACENE-INDUCED EARLY SQUAMOUS-CELL CARCINOMA IN THE GOLDEN SYRIAN-HAMSTER - EVALUATION OF AN ANIMAL-MODEL AND COMPARISON WITH EARLY FORMS OF HUMAN SQUAMOUS-CELL CARCINOMA IN THE UPPER AERODIGESTIVE TRACT, International journal of experimental pathology, 77(1), 1996, pp. 7-14
To test and optimize photodynamic therapy of early cancers in the uppe
r aero-digestive tract and oesophagus, we sought an appropriate animal
model, which was found in the 7,12-dimethylbenz[a]anthracene-induced
early squamous cell carinoma in the Golden Syrian hamster. This chemic
ally induced neoplasm is shown, by histology and immunohistochemistry,
to pass through similar stages of early cancer development as its hum
an counterpart. Its time sequence is highly reproducible, leading to a
well differentiated carcinoma in situ and microinvasive carcinoma in
the hamster cheek pouch over a period of 10 weeks.