7,12-DIMETHYLBENZ[A]ANTHRACENE-INDUCED EARLY SQUAMOUS-CELL CARCINOMA IN THE GOLDEN SYRIAN-HAMSTER - EVALUATION OF AN ANIMAL-MODEL AND COMPARISON WITH EARLY FORMS OF HUMAN SQUAMOUS-CELL CARCINOMA IN THE UPPER AERODIGESTIVE TRACT

Citation
S. Andrejevic et al., 7,12-DIMETHYLBENZ[A]ANTHRACENE-INDUCED EARLY SQUAMOUS-CELL CARCINOMA IN THE GOLDEN SYRIAN-HAMSTER - EVALUATION OF AN ANIMAL-MODEL AND COMPARISON WITH EARLY FORMS OF HUMAN SQUAMOUS-CELL CARCINOMA IN THE UPPER AERODIGESTIVE TRACT, International journal of experimental pathology, 77(1), 1996, pp. 7-14
Citations number
27
Categorie Soggetti
Pathology
ISSN journal
09599673
Volume
77
Issue
1
Year of publication
1996
Pages
7 - 14
Database
ISI
SICI code
0959-9673(1996)77:1<7:7ESCI>2.0.ZU;2-#
Abstract
To test and optimize photodynamic therapy of early cancers in the uppe r aero-digestive tract and oesophagus, we sought an appropriate animal model, which was found in the 7,12-dimethylbenz[a]anthracene-induced early squamous cell carinoma in the Golden Syrian hamster. This chemic ally induced neoplasm is shown, by histology and immunohistochemistry, to pass through similar stages of early cancer development as its hum an counterpart. Its time sequence is highly reproducible, leading to a well differentiated carcinoma in situ and microinvasive carcinoma in the hamster cheek pouch over a period of 10 weeks.