GLUTATHIONE-S-TRANSFERASE AND GAMMA-GLUTAMYL-TRANSPEPTIDASE ACTIVITIES IN CULTURED RAT HEPATOCYTES TREATED WITH TOCOTRIENOL AND TOCOPHEROL

Authors
ONG FB NGAH WZW SHAMAAN NA TOP AGM MARZUKI A KHALID AK
Citation
Fb. Ong et al., GLUTATHIONE-S-TRANSFERASE AND GAMMA-GLUTAMYL-TRANSPEPTIDASE ACTIVITIES IN CULTURED RAT HEPATOCYTES TREATED WITH TOCOTRIENOL AND TOCOPHEROL, Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology, 106(1), 1993, pp. 237-240
Citations number
20
Categorie Soggetti
Biology,"Pharmacology & Pharmacy",Toxicology
Journal title
Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology → ACNP
ISSN journal
07428413
Volume
106
Issue
1
Year of publication
1993
Pages
237 - 240
Database
ISI
SICI code
0742-8413(1993)106:1<237:GAGA>2.0.ZU;2-4
Abstract
1. The effect of tocotrienol and tocopherol on glutathione S-transfera se (GST) and gammaglutamyl transpeptidase (GGT) activities in cultured rat hepatocytes were investigated. 2. Tocotrienol and tocopherol sign ificantly decreased GGT activities at 5 days in culture but tocotrieno l also significantly decreased GGT activities at 1-2 days. 3. Tocotrie nol and tocopherol treatment significantly decreased GST activities at 3 days compared to the control but tocotrienol also decreased GST act ivities at 1-3 days. 4. Tocotrienol showed a more pronounced effect at a dosage of greater than 50 muM tocotrienol at 1-3 days in culture co mpared to the control.