BONE-FORMATION IN THE GOAT MAXILLARY SINUS INDUCED BY ABSORBABLE COLLAGEN SPONGE IMPLANTS IMPREGNATED WITH RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2

Citation
M. Nevins et al., BONE-FORMATION IN THE GOAT MAXILLARY SINUS INDUCED BY ABSORBABLE COLLAGEN SPONGE IMPLANTS IMPREGNATED WITH RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2, The International journal of periodontics & restorative dentistry, 16(1), 1996, pp. 9-19
Citations number
44
Categorie Soggetti
Dentistry,Oral Surgery & Medicine
ISSN journal
01987569
Volume
16
Issue
1
Year of publication
1996
Pages
9 - 19
Database
ISI
SICI code
0198-7569(1996)16:1<9:BITGMS>2.0.ZU;2-O
Abstract
This study assessed the efficacy safely and technical feasibility of i nducing bone formation in an animal model of maxillary sinus floor aug mentation using recombinant human bone morphogenetic protein-2 (rhBMP- 2) impregnated on an absorbable collagen sponge (ACS). Bilateral antra l maxillary sinus floor elevation procedures were surgically performed in six adult female Alpine-Saanen goats. Bone formation in response t o the implant was evaluated using sequential radiographs, computerized tomography and gross pathologic and histologic analysis performed at necropsy. Computerized tomographic scans documented nonosseous radiopa city in both sinuses postimplantation. Sinuses implanted with rhBMP-2/ ACS subsequently demonstrated increasing radiopacity local to the impl ant site, while radiopacity of the negative control sinuses remained u nchanged or decreased. The results demonstrated the ability of an rhBM P-2/ACS implant to induce substantive new bone formation within the ma xillary sinus of goats without adverse sequelae. The rhBMP-2/ACS compo site implant may represent an acceptable alternative to traditional bo ne grafts and bone substitutes for maxillary sinus floor augmentation procedures in humans.