Ik. Kang et al., SURFACE MODIFICATION OF POLYETHERURETHANEUREAS AND THEIR ANTITHROMBOGENICITY, Journal of materials science. Materials in medicine, 7(3), 1996, pp. 135-140
Polyetherurethaneurea (PU) films were treated by oxygen plasma dischar
ge followed by acrylic acid (AA) grafting. The carboxyl groups of the
AA-grafted PU (PU-AA) surface were coupled with bovine serum albumin a
nd heparin via water soluble carbodiimide. Surface characterization of
the modified PUs was carried out by attenuated total reflection Fouri
er transform infrared (ATR-FTIR) spectroscopy and electron spectroscop
y for chemical analysis (ESCA). The amount of immobilized albumin and
heparin on the PU surface was 1.8 and 1.5 mu g/cm(2), respectively, as
determined by the dye interaction method. Interactions between the su
rface-modified PUs and blood components such as plasma proteins and pl
atelets were investigated to evaluate the blood compatibility of the s
amples. Plasma recalcification time (PRT) and activated partial thromb
oplastin time (APTT) of the albumin-immobilized PU (PU-Al) were almost
the same as those of PU, while platelets were less adhered on the PU-
Al than on PU. On the other hand, PRT and APTT of the PU-He were signi
ficantly longer than those of the PU, PU-AA, and PU-Al. Moreover, adhe
sion of platelets was effectively suppressed on the PU-He, leading to
good in vitro blood compatibility.