THE SYNTHESIS OF -2-METHYL-3-OXO-2H-BENZO-1,4-THIAZINE-2-CARBOXYLIC ACIDS

Authors
CIZEJ VL URLEB U
Citation
Vl. Cizej et U. Urleb, THE SYNTHESIS OF -2-METHYL-3-OXO-2H-BENZO-1,4-THIAZINE-2-CARBOXYLIC ACIDS, Journal of heterocyclic chemistry, 33(1), 1996, pp. 97-101
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
33
Issue
1
Year of publication
1996
Pages
97 - 101
Database
ISI
SICI code
0022-152X(1996)33:1<97:TSO-A>2.0.ZU;2-R
Abstract
The synthesis of -2-methyl-3-oxo-2H-benzo-1,4-thiazine-2-carboxylic ac ids 4a,b, 6a-e is presented. After the condensation of o-aminothiophen ols with diethyl 2-bromo-2-methylmalonate in the presence of KF as a c atalyst the nitrogen in the fused derivatives 3a,b, was alkylated to p rovide 5a-f, the corresponding esters 3a,b, 5a-f were hydrolysed.