BINDING AND FUNCTIONAL-EFFECTS OF TRANSCRIPTIONAL FACTOR SP1 ON THE MURINE INTERLEUKIN-8 PROMOTOR

The NF-kappa B and NF-IL6 elements have previously been shown to play an important role in regulation of both the mouse and human interleuki n-6 gene. Between these two elements lies a G/C-rich sequence, which c ontains three repeats of the element CCACC, protein binding to which h as not been previously characterized. In this study we demonstrate tha t the transcription factor Sp1 binds to these repeats and plays an imp ortant role in basal and in inducible expression of the murine interle ukin-6 gene.