Sh. Kang et al., BINDING AND FUNCTIONAL-EFFECTS OF TRANSCRIPTIONAL FACTOR SP1 ON THE MURINE INTERLEUKIN-8 PROMOTOR, The Journal of biological chemistry, 271(13), 1996, pp. 7330-7335
The NF-kappa B and NF-IL6 elements have previously been shown to play
an important role in regulation of both the mouse and human interleuki
n-6 gene. Between these two elements lies a G/C-rich sequence, which c
ontains three repeats of the element CCACC, protein binding to which h
as not been previously characterized. In this study we demonstrate tha
t the transcription factor Sp1 binds to these repeats and plays an imp
ortant role in basal and in inducible expression of the murine interle
ukin-6 gene.