N. Kalyanam et al., STUDIES ON ANTIAMOEBIC COMPOUNDS .4. SYNTHESIS OF HEXAHYDROPYRIMIDINES AND TETRAHYDROIMIDAZOLES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 31(4), 1992, pp. 243-247
Several compounds containing omicron-alkylaminomethylenephenolic group
(Mannich group) incorporating heterocycles such as hexahydropyrimidin
es and tetrahydroimidazoles have been synthesized. Compound 18 has bee
n found to be active against hepatic amoebiasis. Effect of substituent
s on the conformations of hexahydropyrimidines is discussed.