EFFECTS OF METFORMIN ON SGLT1, GLUT2, AND GLUT5 HEXOSE TRANSPORTER GENE-EXPRESSION IN SMALL-INTESTINE FROM RATS

Citation
S. Lenzen et al., EFFECTS OF METFORMIN ON SGLT1, GLUT2, AND GLUT5 HEXOSE TRANSPORTER GENE-EXPRESSION IN SMALL-INTESTINE FROM RATS, Biochemical pharmacology, 51(7), 1996, pp. 893-896
Citations number
29
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
ISSN journal
00062952
Volume
51
Issue
7
Year of publication
1996
Pages
893 - 896
Database
ISI
SICI code
0006-2952(1996)51:7<893:EOMOSG>2.0.ZU;2-D
Abstract
The effect of the antihyperglycaemic agent metformin was studied on ge ne expression of the energy-dependent sodium-hexose cotransporter (SGL T1) and the facilitative hexose transporters GLUT2 and GLUT5 in rat in testine. Metformin treatment (125 mg/kg body wt. twice daily for a per iod of 3 days) significantly increased SGLT1 gene expression in duoden um and jejunum. GLUT5 gene expression was increased by metformin treat ment only in the jejunum; Gene expression of GLUT2 in the intestine wa s not significantly affected by metformin treatment. This increase in transporter gene expression offers the potential for increases in hexo se uptake at the brush border membrane, and may compensate for other e ffects of the drug that have been suggested to decrease glucose uptake by SGLT1, as well as for metformin stimulation of glucose utilization by the intestinal mucosa.