THE STRUCTURE AND LIGAND INTERACTIONS OF CD2 - IMPLICATIONS FOR T-CELL FUNCTION

Considerable progress has recently been made in understanding the stru cture and ligand interactions of the T-cell antigen CD2, to the extent that CD2 is now a useful paradigm for considering the structural basi s of cell-cell recognition. Here, Simon Davis and Anton van der Merwe review the new data and consider their implications and T-cell functio n in the context of CD2-knockout experiments.