THE EFFECTS OF BRISK WALKING ON MARKERS OF BONE AND CALCIUM-METABOLISM IN POSTMENOPAUSAL WOMEN

Weight-bearing exercise has been shown to maintain or increase bone ma ss in younger as well as older individuals but the mechanisms by which mechanical loading affects bone metabolism are not known in detail. T welve postmenopausal women participated in a single bout of brisk walk ing (50% of VO2max) for 90 minutes. Calciotropic hormones and markers of type I collagen formation (PICP) and degradation (ICTP) were measur ed before the exercise, and 1, 24, and 72 hours following the exercise . Total body bone mineral content (BMC) and density (BMD) were measure d by dual energy X-ray absorptiometry (DXA). Brisk walking did not ind uce any significant changes in the concentrations of ionized calcium, parathyroid hormone (PTH), calcitonin, or osteocalcin. A significant i ncrease of PICP was noted 24 and 72 hours (P < 0.01) after exertion an d a significant decrease in the concentration of serum ICTP at 1 hour (P < 0.05) was followed by an increase at 72 hours (P < 0.001). There was no significant difference between the increases in the concentrati ons of PICP and ICTP at 72 hours. Strong inverse correlations between the basal levels of PTH and BMD (r = -0.78; P < 0.01) as well as betwe en osteocalcin and BMD (r = -0.83; P < 0.01) were noticed. The changes in serum levels of bone collagen markers indicate an altered bone col lagen turnover due to this moderate endurance exercise. The results al so support the fact that serum levels of PTH as well as those of osteo calcin are associated with total body BMD in postmenopausal women.