NOVEL ANIONIC THERMOSENSITIVE HYDROGELS

Novel anionic thermosensitive hydrogels were prepared by the copolymer ization of N-isopropyl acrylamide(NIPA) with 3-sulfopropyl acrylate po tassium salt(SPAP) as anionic monomer in the presence of methylene-bis acrylamide (MBA). The hydrogels exhibit excellent thermosensitive beha vior and high swelling properites, In the feed ratios varing from 1.0% to 2.0% (molar ratio) SPAP content the hydrogels possess the volume r atios of 27 similar to 38 and the sensitive temperatures varied from 3 5 degrees C to 38 degrees C , which are very close to the human body t emperature, and very important for Drug Delivery Systems(DDS).