STUDIES ON THE SYNTHESIS OF S-ALKYL-O-POL YCHLOROPHENYL THIOPHOSPHORIC(-NIC) ACID-DERIVATIVES AND THEIR FUNGICIDAL ACTIVITIES

The isomerization/chlorination of O,O-dialkyl thiophosphate (-onate) 1 with phosphorus oxychloride gives S-alkyl thiophosphorochloride (-noc hloride) 2, then, the reaction of compounds 2 with polychlorophenol in the presence of triethlamine afford the title compounds 4. Compounds 4 have also been prepared by using the traditional method, thus, the r eaction of S-alkyl thiophosphorodichloride 5 with polychlorophenol, th en with another nucleophile R'H in the presence of triethylamine can a lso give the title compounds (4). The results of the tests in the fung icidal activity towards the twelve plant disease fungus show that the twenty-eight compounds 4 prepared possess a satisfactory or excellent fungicidal activity.