MDR1 AND MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) GENE-EXPRESSION IN EPITHELIAL OVARIAN-TUMORS

Authors
KAVALLARIS M LEARY JA BARRETT JA FRIEDLANDER ML
Citation
M. Kavallaris et al., MDR1 AND MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) GENE-EXPRESSION IN EPITHELIAL OVARIAN-TUMORS, Cancer letters, 102(1-2), 1996, pp. 7-16
Citations number
33
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
102
Issue
1-2
Year of publication
1996
Pages
7 - 16
Database
ISI
SICI code
0304-3835(1996)102:1-2<7:MAMRP(>2.0.ZU;2-5
Abstract
Clinical drug resistance poses a major problem in the successful treat ment of ovarian cancer. Two genes, MDR1 and MRP, have been found to pl ay a role in the multidrug resistance phenotype of a number of human t umors. Using a sensitive semiquantitative PCR assay we examined 53 pri mary untreated ovarian tumors for expression of both MDR1 and MRP gene s. Approximately one-third of the tumors expressed MDR1 while all the tumors expressed varying levels of the MRP gene.