PATHOPHYSIOLOGY OF URETHRAL OBSTRUCTION

Obstructive uropathy refers to abnormalities in structure or function of the urinary tract caused by impairment of normal flow of urine, and the resulting local and systemic effects of that impairment. Clinic c onsequences of obstructive uropathy are associated with abnormalities in fluid balance, electrolyte metabolism, acid-base balance, and reten tion of metabolic wastes. These consequences are partly due to build u p of intravesical, ureteral, and renal pressure, influx of leukocytes into renal parenchyma resulting in release of cytokines, and alteratio ns in intravascular hemodynamics. This article discusses pathophysiolo gic mechanisms and consequences of obstructive uropathy in cats.