The exact cause of hematuria, dysuria, and urethral obstruction remain
s unknown in a large percentage of naturally occurring cases of feline
lower urinary tract disease (FLUTD). One attractive hypothesis implic
ates viruses as the cause of some idiopathic forms of FLUTD; supportin
g this hypothesis is the fact that a gamma herpesvirus, a calicivirus,
and a retrovirus have been isolated from urine and tissues obtained f
rom cats with this type of disease. Although the clinical course and l
aboratory findings of cats with idiopathic FLUTD are suggestive of an
infectious cause, the question of whether viruses have a pathologic ro
le in some forms of naturally acquired FLUTDs has not been completely
answered.