TRANSLOCATION (Y-1)(Q12-Q12) IN HEMATOLOGIC MALIGNANCIES - REPORT ON 2 NEW CASES, FISH CHARACTERIZATION, AND REVIEW OF THE LITERATURE

Authors
MICHAUX L WLODARSKA I VELLOSO ERP VERHOEF G VANORSHOVEN A MICHAUX JL SCHEIFF JM MECUCCI C VANDENBERGHE H
Citation
L. Michaux et al., TRANSLOCATION (Y-1)(Q12-Q12) IN HEMATOLOGIC MALIGNANCIES - REPORT ON 2 NEW CASES, FISH CHARACTERIZATION, AND REVIEW OF THE LITERATURE, Cancer genetics and cytogenetics, 86(1), 1996, pp. 35-38
Citations number
13
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
86
Issue
1
Year of publication
1996
Pages
35 - 38
Database
ISI
SICI code
0165-4608(1996)86:1<35:T(IHM->2.0.ZU;2-D
Abstract
Translocation(Y;1) (q12;q21) is a rare cytogenetic anomaly occurring i n hematologic disorders thought to affect stem cells. We report here o n two new cases, one end-stage myelofibrosis and one chronic myelomono cytic leukemia. The translocation breakpoints were assessed by convent ional cytogenetic techniques in both cases and by FISH in the second c ase. A partial trisomy of the 1q21-qter region could be demonstrated. The data of the literature are reviewed and the possible pathogenetic mechanisms are discussed.