CLONING AND CHARACTERIZATION OF CDNAS CODING FOR HEAVY AND LIGHT-CHAINS OF A MONOCLONAL-ANTIBODY (MABB23) SPECIFIC FOR HUMAN PLASMA APOLIPOPROTEIN B-100

Authors
KWAK JW CHOI BK LEE DI KANG YK SEO YG CHO WK HAN MH
Citation
Jw. Kwak et al., CLONING AND CHARACTERIZATION OF CDNAS CODING FOR HEAVY AND LIGHT-CHAINS OF A MONOCLONAL-ANTIBODY (MABB23) SPECIFIC FOR HUMAN PLASMA APOLIPOPROTEIN B-100, Gene, 169(2), 1996, pp. 237-239
Citations number
8
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
169
Issue
2
Year of publication
1996
Pages
237 - 239
Database
ISI
SICI code
0378-1119(1996)169:2<237:CACOCC>2.0.ZU;2-W
Abstract
We have determined the nucleotide sequences encoding the heavy and lig ht chains of the Fab fragment of murine monoclonal antibody MabB23 (ga mma 2b, gamma), which is specific for human plasma apolipoprotein B-10 0 of low-density lipoproteins. The sequence analyses revealed that the variable regions of the heavy and light chains are members of mouse h eavy-chain subgroup I(B) and lambda light-chain, respectively. A few u nusual amino acids in the framework and constant regions of the heavy- chain were also noticed.