C. Wanichanon et al., ULTRASTRUCTURAL-CHANGES IN THE INTESTINAL ABSORPTIVE CELLS OF THE MOUSE INDUCED BY CAPSAICIN IN RELATION TO THIAMINE-ABSORPTION, PTR. Phytotherapy research, 10(2), 1996, pp. 136-139
The correlation between an inhibition of thiamine absorption and ultra
structural changes in the intestinal absorptive cells of the mouse jej
unum induced by capsaicin was examined. In mice fed with capsaicin 1 a
nd 2 mg/kg BW/day for 12 weeks, thiamine absorption was inhibited by 2
.7% and 12.5% (p<0.001) respectively, Ultrastructural alterations were
observed in villus absorptive cells of jejunum in mice fed with capsa
icin 1 and 2 mg/kg BW/day for 12 weeks. The most striking ultrastructu
ral changes occurred in mice fed with capsaicin 2 mg/kg BW/day for 12
weeks. The organelle most affected by capsaicin was the mitochondria.
The result shows that the ultrastructural changes of intestinal absorp
tive cells may be associated with the inhibition of thiamine absorptio
n.