VULVAR INTRAEPITHELIAL NEOPLASIA-TREATMENT OUTCOME

One hundred and two patients with vulvar intra-epithelial neoplasia II I (VIN III) were analyzed with respect to age, sites of lesion, presen ce of human papilloma virus (HPV) and recurrence pattern following dif ferent treatment modalities. Recurrences were documented in 64% of pat ients. Patients treated with local excision had a statistically signif icant lower recurrence rate compared to those who underwent laser vapo rization (29% vs 55.8% correspondingly). Recurrence rates were also si gnificantly higher in patients with multifocal/multicentric lesions (P <0.05). A group of young, HPV-positive patients with multifocal/multic entric lesions had the highest recurrence rate. Our data suggest that VIN III should be followed for a long period of time and that a prospe ctive study is required to clarify the effectiveness of the different treatment modalities.