AN UNUSUAL CYTOGENETIC ABNORMALITY INVOLVING CHROMOSOME-1 AND CHROMOSOME-7 IN A CASE OF CHRONIC MYELOMONOCYTIC LEUKEMIA

Authors
PAPADHIMITRIOU SI ABAZIS D REPA C PAPACONSTANTINOU C PAPANASTASIOU C PANGALOS C STAMATELOU M
Citation
Si. Papadhimitriou et al., AN UNUSUAL CYTOGENETIC ABNORMALITY INVOLVING CHROMOSOME-1 AND CHROMOSOME-7 IN A CASE OF CHRONIC MYELOMONOCYTIC LEUKEMIA, Cancer genetics and cytogenetics, 85(1), 1995, pp. 75-77
Citations number
11
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
85
Issue
1
Year of publication
1995
Pages
75 - 77
Database
ISI
SICI code
0165-4608(1995)85:1<75:AUCAIC>2.0.ZU;2-Y
Abstract
We report a case of chronic myelomonocytic leukemia in which cytogenet ic analysis revealed a 47,XY, +1, +der(7)del(7)(q32q36)ins(7;1)(q32;p3 6.3p22) chromosomal constitution. This abnormal karyotype, which as a whole is new to any myeloid malignancy, points to a possible pathogene tic role for the oncogenes MET and FGR on the derivative chromosome 7, and for the CSF1 and JUN genes flanking the breakpoint on chromosome 1.