ORAL IMMUNIZATION WITH A RECOMBINANT CYSTEINE-RICH SECTION OF THE ENTAMOEBA-HISTOLYTICA GALACTOSE-INHIBITABLE LECTIN ELICITS AN INTESTINAL SECRETORY IMMUNOGLOBULIN-A RESPONSE THAT HAS IN-VITRO ADHERENCE INHIBITION-ACTIVITY

Authors
BEVING DE SOONG CJG RAVDIN JI
Citation
De. Beving et al., ORAL IMMUNIZATION WITH A RECOMBINANT CYSTEINE-RICH SECTION OF THE ENTAMOEBA-HISTOLYTICA GALACTOSE-INHIBITABLE LECTIN ELICITS AN INTESTINAL SECRETORY IMMUNOGLOBULIN-A RESPONSE THAT HAS IN-VITRO ADHERENCE INHIBITION-ACTIVITY, Infection and immunity, 64(4), 1996, pp. 1473-1476
Citations number
26
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
64
Issue
4
Year of publication
1996
Pages
1473 - 1476
Database
ISI
SICI code
0019-9567(1996)64:4<1473:OIWARC>2.0.ZU;2-O
Abstract
The LC3-encoded 52-kDa recombinant protein includes amino acids 758 to 1134 of the 170-kDa subunit of the galactose-inhibitable lectin. Oral immunization of BALB/c mice with the LC3-encoded protein and cholera holotoxin induced an intestinal secretory immunoglobulin A (IgA) respo nse (P < 0.01 compared with the control). There was a negative correla tion (P = 0.001) between intestinal anti-LC3 IgA and serum TgA and IgG antibody responses. Intestinal secretions from immunized mice complet ely inhibited the galactose-specific adherence of axenic trophozoites to Chinese hamster ovary cells (P < 0.01).