BINDING BETWEEN OUTER-MEMBRANE PROTEINS OF NONTYPABLE HAEMOPHILUS-INFLUENZAE AND HUMAN NASOPHARYNGEAL MUCIN

Authors
REDDY MS BERNSTEIN JM MURPHY TF FADEN HS
Citation
Ms. Reddy et al., BINDING BETWEEN OUTER-MEMBRANE PROTEINS OF NONTYPABLE HAEMOPHILUS-INFLUENZAE AND HUMAN NASOPHARYNGEAL MUCIN, Infection and immunity, 64(4), 1996, pp. 1477-1479
Citations number
25
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
64
Issue
4
Year of publication
1996
Pages
1477 - 1479
Database
ISI
SICI code
0019-9567(1996)64:4<1477:BBOPON>2.0.ZU;2-O
Abstract
Bacterial colonization of the epithelial cells precedes infection. Muc ins of the epithelial cell secretions modulate bacterial colonization. This study was designed to understand the mechanism of mucin-bacteria l interactions and in particular binding between nontypeable Haemophil us influenzae and nasopharyngeal mucin(s). In an overlay assay, bindin g appears to be mediated by outer membrane proteins P2 and P5 of bacte ria and sialic acid-containing oligosaccharides of mucin.