CD36 AND INTERCELLULAR-ADHESION MOLECULE-1 MEDIATE ADHESION OF DEVELOPING PLASMODIUM-FALCIPARUM GAMETOCYTES

Authors
ROGERS NJ DARAMOLA O TARGETT GAT HALL BS
Citation
Nj. Rogers et al., CD36 AND INTERCELLULAR-ADHESION MOLECULE-1 MEDIATE ADHESION OF DEVELOPING PLASMODIUM-FALCIPARUM GAMETOCYTES, Infection and immunity, 64(4), 1996, pp. 1480-1483
Citations number
33
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
64
Issue
4
Year of publication
1996
Pages
1480 - 1483
Database
ISI
SICI code
0019-9567(1996)64:4<1480:CAIMMA>2.0.ZU;2-C
Abstract
Plasmodium falciparum trophozoite infected erythrocytes adhere to the amelanotic melanoma C32 cell line in vitro. Here we demonstrate for th e first time that immature gametocyte-infected erythrocytes also adher e to C32 cells, albeit at lower levels than trophozoites. However, ant i-CD36 and anti-intercellular adhesion molecule 1 antibodies inhibit a sexual and gametocyte adhesion by comparable percentages, suggesting a common dependency for binding to these cellular receptors.