Sk. Aggarwal et Jm. Fadool, CISPLATIN AND CARBOPLATIN INDUCED CHANGES IN THE NEUROHYPOPHYSIS AND PARATHYROID, AND THEIR ROLE IN NEPHROTOXICITY, Anti-cancer drugs, 4(2), 1993, pp. 149-162
Cytochemical and ultrastructural studies in Wistar rats [Crl: (WI)BR]
show that cisplatin treatment (5-9 mg/kg) induces a release of neurose
cretory granules from the neurohypophysis with a corresponding decreas
e in the urine output in a time and dose dependent fashion. Cisplatin
induces low blood calcium and phosphate levels with a corresponding in
crease in the dark cells of the parathyroid gland. Injections of calci
um before and during the treatment of cisplatin are effective in comba
ting hypocalcemia, nephrotoxicity and gastrointestinal toxicity due to
cisplatin. Carboplatin, a less nephrotoxic agent, does not demonstrat
e any of these changes.