INHIBITION MECHANISMS OF STAUROSPORINE AND H7 TO CAMP-DEPENDENT PROTEIN-KINASE THROUGH DOCKING STUDY

Authors
TAKAGI A MIZUTANI MY TOMIOKA N ITAI A
Citation
A. Takagi et al., INHIBITION MECHANISMS OF STAUROSPORINE AND H7 TO CAMP-DEPENDENT PROTEIN-KINASE THROUGH DOCKING STUDY, Chemical and Pharmaceutical Bulletin, 44(3), 1996, pp. 618-620
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
44
Issue
3
Year of publication
1996
Pages
618 - 620
Database
ISI
SICI code
0009-2363(1996)44:3<618:IMOSAH>2.0.ZU;2-Y
Abstract
Inhibition mechanisms of staurosporine and H7 to cAMP-dependent protei n kinase have been investigated through docking studies. For each mole cule, the energetically most stable docking model was searched by usin g the conformationally flexible automatic docking program ADAM without any presumptions. The results explain well the observation that staur osporine does not bind to the enzyme competitively with H7, even thoug h the two compounds competitively inhibit ATP binding.