INTERACTION OF NEUTRAL AND CHARGED LOCAL-ANESTHETIC WITH PURPLE MEMBRANE

Authors
SHIBATA A UEDA F OKAMOTO E UENO S YAMASHITA T
Citation
A. Shibata et al., INTERACTION OF NEUTRAL AND CHARGED LOCAL-ANESTHETIC WITH PURPLE MEMBRANE, Chemical and Pharmaceutical Bulletin, 44(3), 1996, pp. 621-623
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
44
Issue
3
Year of publication
1996
Pages
621 - 623
Database
ISI
SICI code
0009-2363(1996)44:3<621:IONACL>2.0.ZU;2-#
Abstract
The circular dichroic spectra of a purple membrane (PM) in the presenc e of tetracaine (TTC) showed that neutral TTC lowered the exciton band intensity with a blue shift, whereas charged TTC resulted only in a l owering of the band intensity without the blue shift. This suggests th at there is a difference in the mode of action on the PM between the t wo forms of TTC.